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Off-label means the drug hasnt been approved by the FDA for that specific treatment. Golombek believes that Viagra helps protect against jet lag because the drug raises levels of a small molecule called cyclic guanosine monophosphate cGMP in the body.

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Charles E Grassley R-Iowa, who said the agency had moved far too slowly on an emerging safety concern. Researchers had seen evidence of nitric oxide activity in the clitoris before, but no one had actually looked for PDE5 enzymes or knew exactly where they might be.

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